iNEST (Interconnected Nord-Est Innovation Ecosystem) is a new innovation ecosystem paradigm aimed at creating networks among universities, public research institutes, and highly qualified public and private institutions in Northeastern Italy. The project’s objective is to spread the benefits of digital technologies and develop innovative solutions for cultural dissemination, individual well-being, and economic and entrepreneurial growth. To achieve this, iNEST relies on two key tools: Information and Communication Technologies (ICT) and digitalization. iNEST is structured around a central Hub and 9 Spokes. Each Spoke focuses on a different macro-theme, reflecting the diverse nature of the Italian Northeastern region.