Computational models are bringing novel perspectives into the investigation of cardiovascular issues. Together with imaging improvements, computational tools are increasingly adopted toward the understanding of patient-specific pathological situations, in the development of surgical planning, and in the support of interventional medical decisions. However, the complexity of patient-specific problems calls for an adequate and knowledgeable use of computational tools to obtain valuable results.

In this chapter we introduce a combined parameter and model reduction methodology and present its application to the efficient numerical estimation of a pressure drop in a set of deformed carotids. The aim is to simulate a wide range of possible occlusions after the bifurcation of the carotid. A parametric description of the admissible deformations, based on radial basis functions interpolation, is introduced. Since the parameter space may be very large, the first step in the combined reduction technique is to look for active subspaces in order to reduce the parameter space dimension.

We consider the Navier-Stokes equations in a channel with varying Reynolds numbers. The model is discretized with high-order spectral element ansatz functions, resulting in 14 259 degrees of freedom. The steady-state snapshot solu- tions define a reduced order space, which allows to accurately evaluate the steady- state solutions for varying Reynolds number with a reduced order model within a fixed-point iteration. In particular, we compare different aspects of implementing the reduced order model with respect to the use of a spectral element discretization.

The introduction of computational models in cardiovascular sciences has been progressively bringing new and unique tools for the investigation of the physiopathology. Together with the dramatic improvement of imaging and measuring devices on one side, and of computational architectures on the other one, mathematical and numerical models have provided a new, clearly noninvasive, approach for understanding not only basic mechanisms but also patient-specific conditions, and for supporting the design and the development of new therapeutic options.

We present the results of the application of a parameter space reduction methodology based on active subspaces (AS) to the hull hydrodynamic design problem. Several parametric deformations of an initial hull shape are considered to assess the influence of the shape parameters on the hull wave resistance. Such problem is relevant at the preliminary stages of the ship design, when several flow simulations are carried out by the engineers to establish a certain sensibility with respect to the parameters, which might result in a high number of time consuming hydrodynamic simulations.

In this contribution, we present the results of the application of a parameter space reduction methodology based on active subspaces to the hull hydrodynamic design problem. Several parametric deformations of an initial hull shape are considered to assess the influence of the shape parameters considered on the hull total drag. The hull resistance is typically computed by means of numerical simulations of the hydrodynamic flow past the ship.

POD–Galerkin reduced-order models (ROMs) for fluid-structure interaction problems (incompressible fluid and thin structure) are proposed in this paper. Both the high-fidelity and reduced-order methods are based on a Chorin-Temam operator-splitting approach. Two different reduced-order methods are proposed, which differ on velocity continuity condition, imposed weakly or strongly, respectively. The resulting ROMs are tested and compared on a representative haemodynamics test case characterized by wave propagation, in order to assess the capabilities of the proposed strategies.

In the control field, the study of the system dynamics is usually carried out relying on lumped-parameter or one-dimensional modelling. Even if these approaches are well suited for control purposes since they provide fast-running simulations and are easy to linearize, they may not be sufficient to deeply assess the complexity of the systems, in particular where spatial phenomena have a significant impact on dynamics. Reduced Order Methods (ROM) can offer the proper trade-off between computational cost and solution accuracy.

In this paper we apply a reduced basis framework for the computation of flow bifurcation (and stability) problems in fluid dynamics. The proposed method aims at reducing the complexity and the computational time required for the construction of bifurcation and stability diagrams. The method is quite general since it can in principle be specialized to a wide class of nonlinear problems, but in this work we focus on an application in incompressible fluid dynamics at low Reynolds numbers.

In this work we apply reduced basis methods for parametric PDEs to an isogeometric formulation based on NURBS. The motivation for this work is an integrated and complete work pipeline from CAD to parametrization of domain geometry, then from full order to certified reduced basis solution. IsoGeometric Analysis (IGA) is a growing research theme in scientific computing and computational mechanics, as well as reduced basis methods for parametric PDEs.

In this work we present a reduced basis Smagorinsky turbulence model for steady flows. We approximate the non-linear eddy diffusion term using the Empirical Interpolation Method, and the velocity-pressure unknowns by an independent reduced-basis procedure. This model is based upon an a posteriori error estimation for Smagorinsky turbulence model. The theoretical development of the a posteriori error estimation is based on previous works, according to the Brezzi-Rappaz-Raviart stability theory, and adapted for the non-linear eddy diffusion term.

Several problems in applied sciences and engineering require reduction techniques in order to allow computational tools to be employed in the daily practice, especially in iterative procedures such as optimization or sensitivity analysis. Reduced order methods need to face increasingly complex problems in computational mechanics, especially into a multiphysics setting.

The aim of this work is to solve parametrized partial differential equations in computational domains represented by networks of repetitive geometries by combining reduced basis and domain decomposition techniques. The main idea behind this approach is to compute once, locally and for few reference shapes, some representative finite element solutions for different values of the parameters and with a set of different suitable boundary conditions on the boundaries: these functions will represent the basis of a reduced space where the global solution is sought for.

In this work, two approaches, based on the certified Reduced Basis method, have been developed for simulating the movement of nuclear reactor control rods, in time-dependent non-coercive settings featuring a 3D geometrical framework. In particular, in a first approach, a piece-wise affine transformation based on subdomains division has been implemented for modelling the movement of one control rod. In the second approach, a staircase strategy has been adopted for simulating the movement of all the three rods featured by the nuclear reactor chosen as case study.

In this work, a Reduced Basis method, with basis functions sampled by a Proper Orthogonal Decomposition technique, has been employed to develop a reduced order model of a multi-physics parametrized Lead-cooled Fast Reactor single-channel. Being the first time that a reduced order model is developed in this context, the work focused on a methodological approach and the coupling between the neutronics and the heat transfer, where the thermal feedbacks on neutronics are explicitly taken into account, in time-invariant settings.

The coupling of a free flow with a flow through porous media has many potential applications in several fields related with computational science and engineering, such as blood flows, environmental problems or food technologies. We present a reduced basis method for such coupled problems. The reduced basis method is a model order reduction method applied in the context of parametrized systems. Our approach is based on a heterogeneous domain decomposition formulation, namely the Stokes-Darcy problem. Thanks to an offline/online-decomposition, computational times can be drastically reduced.

In this work we show some results about the reduced basis approximation of advection dominated parametrized problems, i.e. advection-diffusion problems with high Péclet number. These problems are of great importance in several engineering applications and it is well known that their numerical approximation can be affected by instability phenomena. In this work we compare two possible stabilization strategies in the framework of the reduced basis method, by showing numerical results obtained for a steady advection-diffusion problem.

In this paper we develop and analyze a multilevel weighted reduced basis method for solving stochastic optimal control problems constrained by Stokes equations. We prove the analytic regularity of the optimal solution in the probability space under certain assumptions on the random input data. The finite element method and the stochastic collocation method are employed for the numerical approximation of the problem in the deterministic space and the probability space, respectively, resulting in many large-scale optimality systems to solve.

This monograph addresses the state of the art of reduced order methods for modeling and computational reduction of complex parametrized systems, governed by ordinary and/or partial differential equations, with a special emphasis on real time computing techniques and applications in computational mechanics, bioengineering and computer graphics.

We extend the classical empirical interpolation method [M. Barrault, Y. Maday, N.C. Nguyen and A.T. Patera, An empirical interpolation method: application to efficient reduced-basis discretization of partial differential equations. Compt. Rend. Math. Anal. Num. 339 (2004) 667-672] to a weighted empirical interpolation method in order to approximate nonlinear parametric functions with weighted parameters, e.g. random variables obeying various probability distributions.

The stochastic collocation method (Babuška et al. in SIAM J Numer Anal 45(3):1005-1034, 2007; Nobile et al. in SIAM J Numer Anal 46(5):2411-2442, 2008a; SIAM J Numer Anal 46(5):2309-2345, 2008b; Xiu and Hesthaven in SIAM J Sci Comput 27(3):1118-1139, 2005) has recently been applied to stochastic problems that can be transformed into parametric systems. Meanwhile, the reduced basis method (Maday et al.

This chapter reviews techniques of model reduction of fluid dynamics systems. Fluid systems are known to be difficult to reduce efficiently due to several reasons. First of all, they exhibit strong nonlinearities - which are mainly related either to nonlinear convection terms and/or some geometric variability - that often cannot be treated by simple linearization.

Shape optimization problems governed by PDEs result from many applications in computational fluid dynamics. These problems usually entail very large computational costs and require also a suitable approach for representing and deforming efficiently the shape of the underlying geometry, as well as for computing the shape gradient of the cost functional to be minimized. Several approaches based on the displacement of a set of control points have been developed in the last decades, such as the so-called free-form deformations.

In this paper, two modelling approaches based on a Modal Method (MM) and on the Proper Orthogonal Decomposition (POD) technique, for developing a control-oriented model of nuclear reactor spatial kinetics, are presented and compared. Both these methods allow developing neutronics description by means of a set of ordinary differential equations. The comparison of the outcomes provided by the two approaches focuses on the capability of evaluating the reactivity and the neutron flux shape in different reactor configurations, with reference to a TRIGA Mark II reactor.

The solution of inverse problems in cardiovascular mathematics is computationally expensive. In this paper, we apply a domain parametrization technique to reduce both the geometrical and computational complexities of the forward problem and replace the finite element solution of the incompressible Navier-Stokes equations by a computationally less-expensive reduced-basis approximation. This greatly reduces the cost of simulating the forward problem.

In this paper we review and we extend the reduced basis approximation and a posteriori error estimation for steady Stokes flows in affinely parametrized geometries, focusing on the role played by the Brezzi's and Babuška's stability constants. The crucial ingredients of the methodology are a Galerkin projection onto a low-dimensional space of basis functions properly selected, an affine parametric dependence enabling to perform competitive Offline-Online splitting in the computational procedure and a rigorous a posteriori error estimation on field variables.

This work deals with the development and application of reduction strategies for real-time and many query problems arising in fluid dynamics, such as shape optimization, shape registration (reconstruction), and shape parametrization. The proposed strategy is based on the coupling between reduced basis methods for the reduction of computational complexity and suitable shape parametrizations - such as free-form deformations or radial basis functions - for low-dimensional geometrical description.

This work aims at identifying and quantifying uncertainties from various sources in human cardiovascular system based on stochastic simulation of a one-dimensional arterial network. A general analysis of different uncertainties and probability characterization with log-normal distribution of these uncertainties is introduced.