Brittle materials propagate opening cracks under tension. When stress increases beyond a critical magnitude, then quasistatic crack propagation becomes unstable. In the presence of several precracks, a brittle material always propagates only the weakest crack, leading to catastrophic failure. Here, we show that all these features of brittle fracture are fundamentally modified when the material susceptible to cracking is bonded to a hydrogel, a common situation in biological tissues.

Brittle materials fail catastrophically. In consequence of their limited flaw-tolerance, failure occurs by localized fracture and is typically a dynamic process. Recently, experiments on epithelial cell monolayers have revealed that this scenario can be significantly modified when the material susceptible to cracking is adhered to a hydrogel substrate. Thanks to the hydraulic coupling between the brittle layer and the poroelastic substrate, such a composite can develop a toughening mechanism that relies on the simultaneous growth of multiple cracks.

The flagellar swimming of euglenids, which are propelled by a single anterior flagellum, is characterized by a generalized helical motion. The 3D nature of this swimming motion, which lacks some of the symmetries enjoyed by more common model systems, and the complex flagellar beating shapes that power it make its quantitative description challenging. In this work, we provide a quantitative, 3D, highly resolved reconstruction of the swimming trajectories and flagellar shapes of specimens of Euglena gracilis.

Flutter instability in elastic structures subject to follower load, the most important cases being the famous Beck's and Pflüger's columns (two elastic rods in a cantilever configuration, with an additional concentrated mass at the end of the rod in the latter case), have attracted, and still attract, a thorough research interest. In this field, the most important issue is the validation of the model itself of follower force, a nonconservative action which was harshly criticized and never realized in practice for structures with diffused elasticity.

Some euglenids, a family of aquatic unicellular organisms, can develop highly concerted, large-amplitude peristaltic body deformations. This remarkable behaviour has been known for centuries. Yet, its function remains controversial, and is even viewed as a functionless ancestral vestige. Here, by examining swimming Euglena gracilis in environments of controlled crowding and geometry, we show that this behaviour is triggered by confinement.

The J-integral is formulated in a direct manner for a gel consisting of a cross-linked polymer network and a mobile solvent. The form of the J-integral is given for a formulation that exploits the Helmholtz energy density of the gel and expressions are provided for it in both the unswollen reference configuration of the polymer network and in the current swollen configuration of the gel when small strains are superimposed on the swollen state.

Understanding the mechanics of brain embryogenesis can provide insights on pathologies related to brain development, such as lissencephaly, a genetic disease which causes a reduction of the number of cerebral sulci. Recent experiments on brain organoids have confirmed that gyrification, i.e. the formation of the folded structures of the brain, is triggered by the inhomogeneous growth of the peripheral region. However, the rheology of these cellular aggregates and the mechanics of lissencephaly are still matter of debate.

A Finite-Volume based POD-Galerkin reduced order modeling strategy for steady-state Reynolds averaged Navier--Stokes (RANS) simulation is extended for low-Prandtl number flow. The reduced order model is based on a full order model for which the effects of buoyancy on the flow and heat transfer are characterized by varying the Richardson number. The Reynolds stresses are computed with a linear eddy viscosity model. A single gradient diffusion hypothesis, together with a local correlation for the evaluation of the turbulent Prandtl number, is used to model the turbulent heat fluxes.

In this work, we present an extension of the genetic algorithm (GA) which exploits the active subspaces (AS) property to evolve the individuals on a lower dimensional space. In many cases, GA requires in fact more function evaluations than others optimization method to converge to the optimum. Thus, complex and high-dimensional functions may result intractable with the standard algorithm.

We propose a model order reduction technique integrating the Shifted Boundary Method (SBM) with a POD-Galerkin strategy. This approach allows to treat more complex parametrized domains in an efficient and straightforward way. The impact of the proposed approach is threefold.

First, problems involving parametrizations of complex geometrical shapes and/or large domain deformations can be efficiently solved at full-order by means of the SBM, an unfitted boundary method that avoids remeshing and the tedious handling of cut cells by introducing an approximate surrogate boundary.

Reduced-order modeling (ROM) commonly refers to the construction, based on a few solutions (referred to as snapshots) of an expensive discretized partial differential equation (PDE), and the subsequent application of low-dimensional discretizations of partial differential equations (PDEs) that can be used to more efficiently treat problems in control and optimization, uncertainty quantification, and other settings that require multiple approximate PDE solutions.

We consider a Leray model with a nonlinear differential low-pass filter for the simulation of incompressible fluid flow at moderately large Reynolds number (in the range of a few thousands) with under-refined meshes. For the implementation of the model, we adopt the three-step algorithm Evolve-Filter-Relax (EFR). The Leray model has been extensively applied within a Finite Element (FE) framework. Here, we propose to combine the EFR algorithm with a computationally efficient Finite Volume (FV) method.

The present work focuses on the geometric parametrization and the reduced order modeling of the Stokes equation. We discuss the concept of a parametrized geometry and its application within a reduced order modeling technique. The full order model is based on the discontinuous Galerkin method with an interior penalty formulation. We introduce the broken Sobolev spaces as well as the weak formulation required for an affine parameter dependency. The operators are transformed from a fixed domain to a parameter dependent domain using the affine parameter dependency.

A parametric, hybrid reduced order model approach based on the Proper Orthogonal Decomposition with both Galerkin projection and interpolation based on Radial Basis Functions method is presented. This method is tested against a case of turbulent non-isothermal mixing in a T-junction pipe, a common ow arrangement found in nuclear reactor cooling systems. The reduced order model is derived from the 3D unsteady, incompressible Navier-Stokes equations weakly coupled with the energy equation.

We propose a computationally efficient framework to treat nonlinear partial differential equations having bifurcating solutions as one or more physical control parameters are varied. Our focus is on steady bifurcations. Plotting a bifurcation diagram entails computing multiple solutions of a parametrized, nonlinear problem, which can be extremely expensive in terms of computational time.

We introduce reduced order methods as an efficient strategy to solve parametrized non-linear and time dependent optimal flow control problems governed by partial differential equations. Indeed, optimal control problems require a huge computational effort in order to be solved, most of all in a physical and/or geometrical parametrized setting. Reduced order methods are a reliably suitable approach, increasingly gaining popularity, to achieve rapid and accurate optimal solutions in several fields, such as in biomedical and environmental sciences.

In this work we present a Reduced Order Model which is specifically designed to deal with turbulent flows in a finite volume setting. The method used to build the reduced order model is based on the idea of merging/combining projection-based techniques with data-driven reduction strategies. In particular, the work presents a mixed strategy that exploits a data-driven reduction method to approximate the eddy viscosity solution manifold and a classical POD-Galerkin projection approach for the velocity and the pressure fields, respectively.

In the reduced order modeling (ROM) framework, the solution of a parametric partial differential equation is approximated by combining the high-fidelity solutions of the problem at hand for several properly chosen configurations. Examples of the ROM application, in the naval field, can be found in [31, 24]. Mandatory ingredient for the ROM methods is the relation between the high-fidelity solutions and the parameters.

Marine propeller blade shape is constantly studied by engineers to obtain designs that allow for enhanced hydrodynamic performance while reducing vibrations and noise emissions. In such framework, shape parametrization and morphing algorithms are crucial elements of the numerical simulation and prototyping environment required for the evaluation of new blade geometries.

Computational models are bringing novel perspectives into the investigation of cardiovascular issues. Together with imaging improvements, computational tools are increasingly adopted toward the understanding of patient-specific pathological situations, in the development of surgical planning, and in the support of interventional medical decisions. However, the complexity of patient-specific problems calls for an adequate and knowledgeable use of computational tools to obtain valuable results.

In this chapter we introduce a combined parameter and model reduction methodology and present its application to the efficient numerical estimation of a pressure drop in a set of deformed carotids. The aim is to simulate a wide range of possible occlusions after the bifurcation of the carotid. A parametric description of the admissible deformations, based on radial basis functions interpolation, is introduced. Since the parameter space may be very large, the first step in the combined reduction technique is to look for active subspaces in order to reduce the parameter space dimension.

We consider the Navier-Stokes equations in a channel with varying Reynolds numbers. The model is discretized with high-order spectral element ansatz functions, resulting in 14 259 degrees of freedom. The steady-state snapshot solu- tions define a reduced order space, which allows to accurately evaluate the steady- state solutions for varying Reynolds number with a reduced order model within a fixed-point iteration. In particular, we compare different aspects of implementing the reduced order model with respect to the use of a spectral element discretization.

The introduction of computational models in cardiovascular sciences has been progressively bringing new and unique tools for the investigation of the physiopathology. Together with the dramatic improvement of imaging and measuring devices on one side, and of computational architectures on the other one, mathematical and numerical models have provided a new, clearly noninvasive, approach for understanding not only basic mechanisms but also patient-specific conditions, and for supporting the design and the development of new therapeutic options.

We present the results of the application of a parameter space reduction methodology based on active subspaces (AS) to the hull hydrodynamic design problem. Several parametric deformations of an initial hull shape are considered to assess the influence of the shape parameters on the hull wave resistance. Such problem is relevant at the preliminary stages of the ship design, when several flow simulations are carried out by the engineers to establish a certain sensibility with respect to the parameters, which might result in a high number of time consuming hydrodynamic simulations.

In this contribution, we present the results of the application of a parameter space reduction methodology based on active subspaces to the hull hydrodynamic design problem. Several parametric deformations of an initial hull shape are considered to assess the influence of the shape parameters considered on the hull total drag. The hull resistance is typically computed by means of numerical simulations of the hydrodynamic flow past the ship.

POD–Galerkin reduced-order models (ROMs) for fluid-structure interaction problems (incompressible fluid and thin structure) are proposed in this paper. Both the high-fidelity and reduced-order methods are based on a Chorin-Temam operator-splitting approach. Two different reduced-order methods are proposed, which differ on velocity continuity condition, imposed weakly or strongly, respectively. The resulting ROMs are tested and compared on a representative haemodynamics test case characterized by wave propagation, in order to assess the capabilities of the proposed strategies.

In the control field, the study of the system dynamics is usually carried out relying on lumped-parameter or one-dimensional modelling. Even if these approaches are well suited for control purposes since they provide fast-running simulations and are easy to linearize, they may not be sufficient to deeply assess the complexity of the systems, in particular where spatial phenomena have a significant impact on dynamics. Reduced Order Methods (ROM) can offer the proper trade-off between computational cost and solution accuracy.

In this paper we apply a reduced basis framework for the computation of flow bifurcation (and stability) problems in fluid dynamics. The proposed method aims at reducing the complexity and the computational time required for the construction of bifurcation and stability diagrams. The method is quite general since it can in principle be specialized to a wide class of nonlinear problems, but in this work we focus on an application in incompressible fluid dynamics at low Reynolds numbers.

In this work we apply reduced basis methods for parametric PDEs to an isogeometric formulation based on NURBS. The motivation for this work is an integrated and complete work pipeline from CAD to parametrization of domain geometry, then from full order to certified reduced basis solution. IsoGeometric Analysis (IGA) is a growing research theme in scientific computing and computational mechanics, as well as reduced basis methods for parametric PDEs.

In this work we present a reduced basis Smagorinsky turbulence model for steady flows. We approximate the non-linear eddy diffusion term using the Empirical Interpolation Method, and the velocity-pressure unknowns by an independent reduced-basis procedure. This model is based upon an a posteriori error estimation for Smagorinsky turbulence model. The theoretical development of the a posteriori error estimation is based on previous works, according to the Brezzi-Rappaz-Raviart stability theory, and adapted for the non-linear eddy diffusion term.

Several problems in applied sciences and engineering require reduction techniques in order to allow computational tools to be employed in the daily practice, especially in iterative procedures such as optimization or sensitivity analysis. Reduced order methods need to face increasingly complex problems in computational mechanics, especially into a multiphysics setting.

The aim of this work is to solve parametrized partial differential equations in computational domains represented by networks of repetitive geometries by combining reduced basis and domain decomposition techniques. The main idea behind this approach is to compute once, locally and for few reference shapes, some representative finite element solutions for different values of the parameters and with a set of different suitable boundary conditions on the boundaries: these functions will represent the basis of a reduced space where the global solution is sought for.

In this work, two approaches, based on the certified Reduced Basis method, have been developed for simulating the movement of nuclear reactor control rods, in time-dependent non-coercive settings featuring a 3D geometrical framework. In particular, in a first approach, a piece-wise affine transformation based on subdomains division has been implemented for modelling the movement of one control rod. In the second approach, a staircase strategy has been adopted for simulating the movement of all the three rods featured by the nuclear reactor chosen as case study.

In this work, a Reduced Basis method, with basis functions sampled by a Proper Orthogonal Decomposition technique, has been employed to develop a reduced order model of a multi-physics parametrized Lead-cooled Fast Reactor single-channel. Being the first time that a reduced order model is developed in this context, the work focused on a methodological approach and the coupling between the neutronics and the heat transfer, where the thermal feedbacks on neutronics are explicitly taken into account, in time-invariant settings.

The coupling of a free flow with a flow through porous media has many potential applications in several fields related with computational science and engineering, such as blood flows, environmental problems or food technologies. We present a reduced basis method for such coupled problems. The reduced basis method is a model order reduction method applied in the context of parametrized systems. Our approach is based on a heterogeneous domain decomposition formulation, namely the Stokes-Darcy problem. Thanks to an offline/online-decomposition, computational times can be drastically reduced.

In this work we show some results about the reduced basis approximation of advection dominated parametrized problems, i.e. advection-diffusion problems with high Péclet number. These problems are of great importance in several engineering applications and it is well known that their numerical approximation can be affected by instability phenomena. In this work we compare two possible stabilization strategies in the framework of the reduced basis method, by showing numerical results obtained for a steady advection-diffusion problem.

In this paper we develop and analyze a multilevel weighted reduced basis method for solving stochastic optimal control problems constrained by Stokes equations. We prove the analytic regularity of the optimal solution in the probability space under certain assumptions on the random input data. The finite element method and the stochastic collocation method are employed for the numerical approximation of the problem in the deterministic space and the probability space, respectively, resulting in many large-scale optimality systems to solve.

This monograph addresses the state of the art of reduced order methods for modeling and computational reduction of complex parametrized systems, governed by ordinary and/or partial differential equations, with a special emphasis on real time computing techniques and applications in computational mechanics, bioengineering and computer graphics.

We extend the classical empirical interpolation method [M. Barrault, Y. Maday, N.C. Nguyen and A.T. Patera, An empirical interpolation method: application to efficient reduced-basis discretization of partial differential equations. Compt. Rend. Math. Anal. Num. 339 (2004) 667-672] to a weighted empirical interpolation method in order to approximate nonlinear parametric functions with weighted parameters, e.g. random variables obeying various probability distributions.

The stochastic collocation method (Babuška et al. in SIAM J Numer Anal 45(3):1005-1034, 2007; Nobile et al. in SIAM J Numer Anal 46(5):2411-2442, 2008a; SIAM J Numer Anal 46(5):2309-2345, 2008b; Xiu and Hesthaven in SIAM J Sci Comput 27(3):1118-1139, 2005) has recently been applied to stochastic problems that can be transformed into parametric systems. Meanwhile, the reduced basis method (Maday et al.

This chapter reviews techniques of model reduction of fluid dynamics systems. Fluid systems are known to be difficult to reduce efficiently due to several reasons. First of all, they exhibit strong nonlinearities - which are mainly related either to nonlinear convection terms and/or some geometric variability - that often cannot be treated by simple linearization.

Shape optimization problems governed by PDEs result from many applications in computational fluid dynamics. These problems usually entail very large computational costs and require also a suitable approach for representing and deforming efficiently the shape of the underlying geometry, as well as for computing the shape gradient of the cost functional to be minimized. Several approaches based on the displacement of a set of control points have been developed in the last decades, such as the so-called free-form deformations.

In this paper, two modelling approaches based on a Modal Method (MM) and on the Proper Orthogonal Decomposition (POD) technique, for developing a control-oriented model of nuclear reactor spatial kinetics, are presented and compared. Both these methods allow developing neutronics description by means of a set of ordinary differential equations. The comparison of the outcomes provided by the two approaches focuses on the capability of evaluating the reactivity and the neutron flux shape in different reactor configurations, with reference to a TRIGA Mark II reactor.

The solution of inverse problems in cardiovascular mathematics is computationally expensive. In this paper, we apply a domain parametrization technique to reduce both the geometrical and computational complexities of the forward problem and replace the finite element solution of the incompressible Navier-Stokes equations by a computationally less-expensive reduced-basis approximation. This greatly reduces the cost of simulating the forward problem.

In this paper we review and we extend the reduced basis approximation and a posteriori error estimation for steady Stokes flows in affinely parametrized geometries, focusing on the role played by the Brezzi's and Babuška's stability constants. The crucial ingredients of the methodology are a Galerkin projection onto a low-dimensional space of basis functions properly selected, an affine parametric dependence enabling to perform competitive Offline-Online splitting in the computational procedure and a rigorous a posteriori error estimation on field variables.

This work deals with the development and application of reduction strategies for real-time and many query problems arising in fluid dynamics, such as shape optimization, shape registration (reconstruction), and shape parametrization. The proposed strategy is based on the coupling between reduced basis methods for the reduction of computational complexity and suitable shape parametrizations - such as free-form deformations or radial basis functions - for low-dimensional geometrical description.

This work aims at identifying and quantifying uncertainties from various sources in human cardiovascular system based on stochastic simulation of a one-dimensional arterial network. A general analysis of different uncertainties and probability characterization with log-normal distribution of these uncertainties is introduced.